Pemanfaatan Kadar Granulosit Sebagai Prediktor Risiko Infeksi dan Keluaran Fungsional pada Penderita Stroke Akut

Fadil*, Wardah Rahmatul Islamiyah**
* Peserta PPDS Departemen Neurologi FK Universitas Airlangga – RSUD Dr. Soetomo Surabaya
** Staf pengajar Departemen Neurologi FK Universitas Airlangga/RSUD Dr. Soetomo Surabaya

Abstract

         Latar belakang: Pada penderita stroke akut, granulosit berperan dalam proses terjadinya Stroke associated infection (SAI). Kejadian SAI akan menyebabkan buruknya keluaran klinis fungsional penderita stroke. Tujuan: Mengetahui peran jumlah granulosit pada stroke akut dalam memperkirakan risiko SAI dan keluaran klinis fungsional penderita stroke akut. Metode: jenis penelitian ini adalah observasional analitik dengan rancangan penelitian cross sectional study. Metode pengambilan sampel dengan cara consecutive sampling pada pasien stroke akut yang memenuhi kriteria inklusi dan eksklusi. Subyek penelitian yang datang ke IRD RSUD dr. Soetomo Surabaya akan diambil darahnya untuk dilakukan pemeriksaan jumlah granulosit. Kemudian subyek dinilai ada tidaknya tanda dan gejala SAI serta dinilai keluaran klinis fungsional penderita dan pada hari ke 3 dan ke 7 perawatan di ruangan saraf dengan menggunakan sistem skoring Glasgow outcome scale (GOS). Hasil: Didapatkan angka kejadian SAI pada penelitian ini sebesar 15.4%, dimana tidak didapatkan perbedaan signifikan kadar granulosit antara kelompok SAI dan tidak (p=0.938) serta tidak ada korelasi antara kadar granulosit dengan SAI (p = 0.102). Terdapat korelasi negatif kuat antara kadar granulosit saat MRS dengan keluaran fungsional stroke (GOS) pada hari ke-7 (r = -0.629, p = 0.01). Kesimpulan: Tidak ada korelasi antara kadar granulosit dengan SAI, namun terdapat korelasi negatif kuat antara kadar granulosit saat MRS dengan keluaran fungsional stroke (GOS). Pada penelitian ditemukan beberapa prediktor keluaran fungsional stroke yaitu kadar granulosit saat MRS dan skor NIHSS saat MRS.

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